Te fibrosis ate

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Uiui Tāpirihia ki te Kete

Whakaahuatanga Hua

Te fibrosis ate

● Nga tohu me nga take

Ko te fibrosis ate he tukanga pathophysiological e pa ana ki te hyperplasia rereke o te kiko hono i roto i te ate na nga momo pathogenic, tae atu ki te hepatitis viral, ate waipiro, ate ngako, mate autoimmune. Ko nga whara o te ate he tukanga o te fibrosis ate i roto i te tukanga o te whakatika me te whakaora ate, a, ki te kore e taea te tango i nga mea kino mo te wa roa, ka tupu te tukanga whakamutunga o te fibrosis ki te cirrhosis, ka puta ki te hepatocarcinoma me te mate. Na, he mea nui kia nui ake te aro atu.

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Yu-Long Bao et al. Tuhinga o mua. 2021.

● Tauira kei te waahi 【Rā➡Nga Tauira】

● CCl4 Induced C57BL/6 Liver Fibrosis Model

【Mechanism】I roto i nga kararehe, he maha nga take o te cirrhosis kua rangahaua, engari ko te tauira o te ate ate ate matua i ahu mai i runga i te tono tukurua o te waro tetrachloride (CCl4) mo etahi wiki. Ko te CCl4 he hepatotoxin e puta ai te necrosis ate o te puku o te puku, te tukunga o te cytokine proinflammatory me te profibrotic, me te whakahoahoatanga o te metabolic i roto i te ate, na reira, ka puta te fibrosis ate tae noa ki te cirrhosis i muri i te wa roa.

Ko te whakahaerenga o te CCl4 e mohiotia ana ki te whakararu i te paitini i roto i te ate na roto i te whakaputa metabolites tino tauhohenga, ka puta he kino kino ki nga pūtau ate ka puta ki te fibrosis.

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