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Liver Fibrosis

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Product Description

Liver Fibrosis

● Symptoms and Causes

Liver fibrosis is a pathophysiological process that refers to abnormal hyperplasia of connective tissue within the liver caused by various pathogenic factors, including viral hepatitis, alcoholic liver, fatty liver, autoimmune diseases. Any liver injury has a process of liver fibrosis in the process of liver repair and healing, and if the damage factors cannot be removed for a long time, the last process of fibrosis will develop into cirrhosis, which usually leads to hepatocarcinoma and death. So, it is important to pay more attention to it.

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Yu-Long Bao et al. Front Pathol. 2021.

● Models in place 【Date➡Models】

●CCl4 Induced C57BL/6 Liver Fibrosis Model

【Mechanism】In animals, various causes of cirrhosis have been studied, but the main hepatic cirrhosis model is based on repeated application of carbon tetrachloride (CCl4) over a period of several weeks. CCl4 is a hepatotoxin that causes lobular central hepatic necrosis, proinflammatory and profibrotic cytokine release, and the metabolic activation in the liver, consequently, results in liver fibrosis and even cirrhosis after long-term exposure.

The administration of CCl4 is known to induce toxicity in the liver by producing highly reactive metabolites, resulting in severe damage to liver cells and subsequently developing into fibrosis.

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