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Atopic DERMATITIS, NHP

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Atopic Dermatitis (AD)

● Symptomata et causas

Atopic Dermatitis aegris clinically praesens cutis erythematous plaques, eruptio, elevatur Serum IGE et T adiutorium cellula type II (Th2) Cytokine campester, ut IL-IV et II-XIII. Microscopically, atopic Dermatitis aegris etiam ostende epidermal hyperplasia et cumulus mast cellulis et th th2.

In aliquibus, atopic DERMATITIS est ad a gene variation qui afficit cute facultatem providere tutela. In aliis, atopic DERMATITIS causa nimia bacteria Staphylococcus aureus cutem.

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Guttman-Yassky E, Dhingra N, Leung d. Novum era de biologic therapeutics in atopic DERMATITIS. Peritus Opin Biol. MMXIII; XIII (IV) 549-561.

● exempla in loco 【Date➡models】

● DNCB adductus NHP ad Model

【Mechanism】 homicidia sunt parva moleculae irritants quod ligare ad proteins et elicit an immune responsio et longum esse solebat studere allergic contactus DERMATITIS (ACD). Repetita hapten challenges perturbare ad cutis obice, combined cum th2-biased immune responsio.

Plerique happy, ut 2,4-dinitrochlorobenzenen (dncb) et oxazolone (oxa), inducere a responsione subcinctus a TH1 ad TH ^ ut Cutis DERMATITIS ad ATOPIC DERMATITIS, sicut cutis laesum.

1a8266ca9479be61b1ed5e3222fa875 f45f9a30ee6093648ea5392d1d958 NHP 特应性皮炎 ad 模型介绍 -20230629-BW_20240613091419