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Atopic Dermatitis-NHP

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Product Description

Atopic Dermatitis (AD)

● Symptoms and Causes

Atopic dermatitis patients clinically present skin erythematous plaques, eruption, elevated serum IgE and T helper cell type 2(Th2) cytokine levels, such as IL-4 and IL-13. Microscopically, atopic dermatitis patients also show epidermal hyperplasia and accumulation of mast cells and Th2.

In some people, atopic dermatitis is related to a gene variation that affects the skin's ability to provide protection. In other people, atopic dermatitis is caused by too much of the bacteria Staphylococcus aureus on the skin.

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Guttman-Yassky E, Dhingra N, Leung DY. New era of biologic therapeutics in atopic dermatitis. Expert Opin Biol Ther. 2013;13(4):549-561.

● Models in place 【Date➡Models】

●DNCB Induced NHP AD Model

【Mechanism】Haptens are small molecule irritants that bind to proteins and elicit an immune response and have long been used to study allergic contact dermatitis (ACD). Repeated hapten challenges disrupt the skin barrier, combined with a Th2-biased immune response.

The majority of haptens, such as 2,4-dinitrochlorobenzenen(DNCB) and oxazolone(OXA), induce a response shift from Th1 to Th2 is observed following repeated application of hapten, in other words, contact dermatitis to atopic dermatitis-like skin lesion.

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