Age-related macular degeneratum

Age-related macular degeneratum

● Symptomata et causas  

Age-related macular degeneratum afficit photoreceptors, in pede pigmento epithelium, in Bruch membrana, et choriocapillaris (intimi layer choroideo) in Macula vision in centralis. AMD est multifactorial morbo ad senex, geneticae susceptibilitatem et environmental Risk factores. Senescens-related mutationes includit augendae resistentia, rarefication, et damnum choriocapillaris, lipidorum et lipoprotein depositionem in Bruch membrana, et reductionem in Photoreceptor density. In Povis, hae mutationes, copulata inveterata inflammatio, mutata lipidorum et lipoprotein depositione, augetur oxidative accentus, et minus firmae ab extracellular matrix sustentationem, ducunt ad formationem extracellular quibus lipids, mineralibus, aut proteins, nempe in lipids, mineralibus, aut proteins, nimirum, in Mineribus, aut Dislationes et medium AMD. Progressio AMD est propria progreditur photoreceptor et pede pigmento epithelium degeneratum, quod includit migratio retinalis pigments epithelium cellulis ex originali affectum ad de Bruch in Membranus in interiore lateribus in retina. Geneticae susceptibilitatem ludit substantial partes in Etiologiam de Pov. Genome-wide consociatio studiis relata genes involved in biologicis tractus quod includit inflammatio et immunitatem, lipidorum metabolismi et onerariis, cellular accentus et adscribere cum AMD, VII in II major loci, cfh8-11 et arma environmental Periculum enim est maxime constanter nuntiavit Risk Periculum Pentium AMD.

Jama.2024; CCCXXXI (II) 147-157.Doi: 10.1001 / Jama.2023.26074