ALPECIA Areata

ALPECIA Areata

● Symptomata et causas  

In aa, stimulators factors potest activate CD8 + NKG2D + T cellulis et producendum ifn-γ via jak1 et jak3 meatus. Ifn-γ potest augendae productio II-XV in follicular epithelial cellulis per Jak1 et Jak2. IL-XV Tunc ligat ad CD8 + NKG2D + T cellulis ad producendum magis IFN, γ, quod amplificare positivum feedback loop. Ifn-γ promovet capillos folliculus immune privilegio ruina, quae ducit ad nuditatem autoantigens ad CD8 + NKG2D + T cellulis et faciliorem autoimmune impetum in capillos folliculis. Interea alii inflammatione cellulis, ut DS, CD4 + T cellulis, NK T cellulis, mast cellulis et eosinophils, cumulare circa capillos bulbi.

Zhou, C. Li, X., Wang, C. et al. Alopecia Areata, an update in etiopatogenesis, diagnosis et administratione. Clinic Psalm Allerg Immunol LXI, 403-423 (MMXXI). https://doi.org/10.1007/s12016-021-08883-0