Experimental Allergic Encephalomyelitis (EAE)

HKB's Mouse Experimental Allergic Encephalomyelitis Models provide pharmaceutical researchers with the primary translational platform for multiple sclerosis drug development. Our validated rodent models utilize MOG35-55 peptide immunization, T-cell transfer, or spontaneous models representing various MS phenotypes including relapsing-remitting and progressive forms. These models replicate key features of MS including CNS demyelination, axonal loss, and neuroinflammation. Comprehensive endpoints include clinical disease scoring, motor function assessment, and histopathological analysis of demyelination and axonal damage.