Antineutrophil cytoplasmic antibody (ANCA)-associated vasculitis

HKB's Mouse ANCA-Associated Vasculitis Models provide pharmaceutical researchers with robust platforms for investigating this group of small vessel vasculitides including granulomatosis with polyangiitis and microscopic polyangiitis. Our validated rodent models utilize MPO-ANCA passive transfer or immunization approaches to replicate key features of ANCA-associated vasculitis including necrotizing vasculitis, granulomatous inflammation, and glomerulonephritis.