Collagen Induced Arthritis (CIA)

HKB's Mouse Collagen-Induced Arthritis Models provide pharmaceutical researchers with the gold-standard platform for rheumatoid arthritis drug development. Our validated rodent models utilize bovine or chicken type II collagen immunization to induce robust, symmetric polyarthritis with high incidence and minimal mortality. These models replicate key features of RA including synovial inflammation, pannus formation, cartilage destruction, and bone erosion.