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Inflammatory Bowel Disease-NHP

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Product Description

Inflammatory Bowel Disease (IBD)

● Symptoms and Causes

Inflammatory bowel disease (IBD) is a term that describes disorders involving long-standing (chronic) inflammation of tissues in digestive tract. Inflammatory bowel diseases (IBD) describe a group ofcomplex intestinal disorders characterized by inflammation in the gastrointestinal tract (GIT) and are manifested in two main forms, ulcerative colitis (UC) and Crohn's disease (CD).

The exact cause of IBD is unknown. However, several factors can increase your risk of developing UC and Crohn’s disease, such as the immune system, smoking, ethnicity and Environmental factors.

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https://doi.org/10.1016/S0140-6736(12)60150-0

● Models in place 【Date➡Models】

●DSS Induced NHP IBD Model

【Mechanism】Inflammatory bowel diseases (IBD), mainly comprising ulcerative colitis and Crohn's Disease, are complex and multifactorial diseases with unknown etiology. For the past 20 years, to study human IBD mechanistically, a number of murine models of colitis have been developed. These models are indispensable tools to decipher underlying mechanisms of IBD pathogenesis as well as to evaluate a number of potential therapeutics. Among various chemically induced colitis models, the dextran sulfate sodium (DSS)-induced colitis model is widely used because of its simplicity and many similarities with human ulcerative colitis. This model has both advantages and disadvantages that must be considered when employed.

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