Passive heymann nephritis

Membranous Nephropathy

● Symptoms and Causes  

Membranous nephropathy (MN) occurs at all ages but predominantly among males, with a mean age of diagnosis at the fifties and sixties. It is the second and third leading cause of end-stage renal disease amid primary glomerular diseases in America and Europe, respectively. 

MN is an autoimmune disease, presenting with immune complex deposition between the podocyte and the glomerular basement membrane. With the damage of integrity of podocytes, a large amount of protein is lost in the urine. Heavy proteinuria brings about hypoalbuminemia, anasarca, and hypercoagulability. With persistent proteinuria, about 40–50% of patients develop renal failure within ten years. 

Ronco P, Beck L, Debiec H, et al. Membranous nephropathy. Nat Rev Dis Primers. 2021;7(1):69. Published 2021 Sep 30. doi:10.1038/s41572-021-00303-z

 ● Models in place 【Date➡Models】