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T cell dependent antibody response-NHP

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Product Description

TDAR

● Symptoms and Causes

The T-cell-dependent antibody response (TDAR) to an antigen is a gold standard for assessing the impact of a drug on immune-competence at the preclinical stage of drug discovery. This model is a measure of immune function, which is dependent upon the effectiveness of multiple immune processes, including antigen uptake and presentation, T cell help, B cell activation, and antibody production.

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DOI: DOI 10.1007/s00005-012-0189-7

● Models in place 【Date➡Models】

●KLH Induced TDAR NHP Model

【Mechanism】Keyhole limpet hemocyanin(KLH) is a protein with high immunogenicity, which can elicit T-cell-dependent antibody response (TDAR). In recent years, the utility of the primary response to KLH (i.e., formation of anti-KLH IgM antibody) has been demonstrated to serve as a mechanism model to detect any immunosuppressive potential of new drug entities.

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