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Psoriasis-NHP

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Product Description

Psoriasis

● Symptoms and Causes

Psoriasis is a skin disease that causes a rash with itchy, scaly patches, most commonly on the knees, elbows, trunk and scalp.

Psoriasis is thought to be an immune system problem that causes skin cells to grow faster than usual. In the most common type of psoriasis, known as plaque psoriasis, this rapid turnover of cells results in dry, scaly patches.

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Oliveira ALB, Monteiro VVS; Resveratrol Role in Autoimmune Disease-A Mini-Review. Nutrients. 2017 Dec 1;9(12):1306. doi: 10.3390/nu9121306.

● Models in place 【Date➡Models】

●IMQ Induced NHP Psoriasis Model

【Mechanism】Imiquimod (IMQ), a Toll-like receptor agonist, forms an immune complex with endogenous molecules when induced, and its interaction with TLR induces the production of type ⅰ IFN-α, leading to psoriasis-like skin injury in its own feedback loop.

Our IMQ induced NHP Psoriasis model shows Erythema, Scaling and thickening clinical symptoms in skin and evokes similar cytokines which mimics human psoriasis disease.

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