Xerophthalmia
● Symptoms and Causes
The prevalence of dry eye increases with age; it has been reported to be 6% among 40 year olds, increasing to 25% among those over 65 years of age. Dry eye is caused by an imbalance between tear-related components due to factors such as reduced tear production and the excessive evaporation of tears from the ocular surface. The symptoms of dry eye include blurred vision, photophobia (light sensitivity), and eye irritation, including feelings of irritation and dryness.
Ling J, Chan BC, Tsang MS, Gao X, Leung PC, Lam CW, Hu JM, Wong CK. Current Advances in Mechanisms and Treatment of Dry Eye Disease: Toward Anti-inflammatory and Immunomodulatory Therapy and Traditional Chinese Medicine. Front Med (Lausanne). 2022 Jan 17;8:815075. doi: 10.3389/fmed.2021.815075.
● Models in place 【Date➡Models】
●SCOP Induced Xerophthalmia Model in Rodent 【Mechanism】Scopolamine (SCOP) is a non-specific muscarinic antagonist blocks the lacrimal gland associated nerve pathways to intervene the tear production and composition. SCOP induced dry eye model is widely used for related drug evaluation. |
Xerophthalmia
● Symptoms and Causes
The prevalence of dry eye increases with age; it has been reported to be 6% among 40 year olds, increasing to 25% among those over 65 years of age. Dry eye is caused by an imbalance between tear-related components due to factors such as reduced tear production and the excessive evaporation of tears from the ocular surface. The symptoms of dry eye include blurred vision, photophobia (light sensitivity), and eye irritation, including feelings of irritation and dryness.
Ling J, Chan BC, Tsang MS, Gao X, Leung PC, Lam CW, Hu JM, Wong CK. Current Advances in Mechanisms and Treatment of Dry Eye Disease: Toward Anti-inflammatory and Immunomodulatory Therapy and Traditional Chinese Medicine. Front Med (Lausanne). 2022 Jan 17;8:815075. doi: 10.3389/fmed.2021.815075.
● Models in place 【Date➡Models】
●SCOP Induced Xerophthalmia Model in Rodent 【Mechanism】Scopolamine (SCOP) is a non-specific muscarinic antagonist blocks the lacrimal gland associated nerve pathways to intervene the tear production and composition. SCOP induced dry eye model is widely used for related drug evaluation. |