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Neuropathic pain

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Neuropathic Pain

● Symptoms and Causes

Neuropathic pain is often described as a shooting or burning pain. It can go away on its own but is often chronic. It often is the result of nerve damage or a malfunctioning nervous system. The impact of nerve damage is a change in nerve function both at the site of the injury and areas around it.

Neuropathic pain often seems to have no obvious cause. But some common causes of neuropathic pain include chemotherapy, diabetes, facial nerve problems, multiple myeloma, multiple sclerosis, nerve or spinal cord compression from herniated discs or from arthritis in the spine, shingles, spine surgery, syphilis, thyroid problems etc.

Pain-resolving immune mechanisms in neuropathic pain(科研通-ablesci.com)-8

Fiore, N.T., Debs, S.R., Hayes, J.P. et al. Pain-resolving immune mechanisms in neuropathic pain. Nat Rev Neurol 19, 199–220 (2023). https://doi.org/10.1038/s41582-023-00777-3

● Models in place 【Date➡Models】

●SNI&SNL surgery Induced Neuropathic Pain Model

【Mechanism】Researchers have developed four widely used preclinical nerve injury models in order to replicate the symptoms of neuropathic pain. They involve damaging a portion of axons which contribute to the sciatic nerve, and from greatest to least neuronal damage include spinal nerve ligation (SNL), where the L5 and/or L6 spinal nerves are ligated; spared nerve injury (SNI), where the tibial and common peroneal sciatic nerve branches are tightly ligated then transected; partial sciatic nerve ligation (PSNL), and chronic constriction injury (CCI). In general, these peripheral nerve injury models have similar time courses of sensory symptoms (emerging within 24 h and persisting >2 months. Further, the SNI model uniquely fails to produce thermal hyperalgesia, this may be explained by a lack of denervated Schwann cells which are known to produce many neuroactive molecules capable of acting on intact axons.

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