Sjogren's syndrome (SjS)
● Symptoms and Causes
Sjogren's (SHOW-grins) syndrome is a disorder of your immune system identified by its two most common symptoms — dry eyes and a dry mouth. The condition often accompanies other immune system disorders, such as rheumatoid arthritis and lupus. In Sjogren's syndrome, the mucous membranes and moisture-secreting glands of your eyes and mouth are usually affected first — resulting in decreased tears and saliva.
Certain genes put people at higher risk of the disorder, but it appears that a triggering mechanism — such as infection with a particular virus or strain of bacteria — is also necessary.
Parisis D, Chivasso C, Perret J, Soyfoo MS, Delporte C. Current State of Knowledge on Primary Sjögren's Syndrome, an Autoimmune Exocrinopathy. J Clin Med. 2020;9(7):2299. Published 2020 Jul 20.
● Models in place 【Date➡Models】
●Salivary Gland Protein Induced NHP SjS Model 【Mechanism】Similar to induced models of many other autoimmune diseases, the first induced model of SjS was established by immunizing animals with tissue/cell extracts. |
Sjogren's syndrome (SjS)
● Symptoms and Causes
Sjogren's (SHOW-grins) syndrome is a disorder of your immune system identified by its two most common symptoms — dry eyes and a dry mouth. The condition often accompanies other immune system disorders, such as rheumatoid arthritis and lupus. In Sjogren's syndrome, the mucous membranes and moisture-secreting glands of your eyes and mouth are usually affected first — resulting in decreased tears and saliva.
Certain genes put people at higher risk of the disorder, but it appears that a triggering mechanism — such as infection with a particular virus or strain of bacteria — is also necessary.
Parisis D, Chivasso C, Perret J, Soyfoo MS, Delporte C. Current State of Knowledge on Primary Sjögren's Syndrome, an Autoimmune Exocrinopathy. J Clin Med. 2020;9(7):2299. Published 2020 Jul 20.
● Models in place 【Date➡Models】
●Salivary Gland Protein Induced NHP SjS Model 【Mechanism】Similar to induced models of many other autoimmune diseases, the first induced model of SjS was established by immunizing animals with tissue/cell extracts. |