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Sjogren's Syndrome-NHP

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Sjogren's syndrome (SjS) 

● Symptoms and Causes  

Sjogren's (SHOW-grins) syndrome is a disorder of your immune system identified by its two most common symptoms — dry eyes and a dry mouth. The condition often accompanies other immune system disorders, such as rheumatoid arthritis and lupus. In Sjogren's syndrome, the mucous membranes and moisture-secreting glands of your eyes and mouth are usually affected first — resulting in decreased tears and saliva.

Certain genes put people at higher risk of the disorder, but it appears that a triggering mechanism — such as infection with a particular virus or strain of bacteria — is also necessary.

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Parisis D, Chivasso C, Perret J, Soyfoo MS, Delporte C. Current State of Knowledge on Primary Sjögren's Syndrome, an Autoimmune Exocrinopathy. J Clin Med. 2020;9(7):2299. Published 2020 Jul 20.


 ● Models in place 【Date➡Models】

Salivary Gland Protein Induced NHP SjS Model

【Mechanism】Similar to induced models of many other autoimmune diseases, the first induced model of SjS was established by immunizing animals with tissue/cell extracts.

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NHP 干燥综合征-NHP SjS模型介绍-20230509_20240612104307



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