Home » Services » Autoimmune Disease Animal Models-Small Animals » Fibrotic Related Diseases » Idiopathic pulmonary fibrosis

Idiopathic pulmonary fibrosis

Quantity:
Availability:





Inquire Add to Basket

Product Description

Idiopathic Pulmonary Fibrosis (IPF)

● Symptoms and Causes

The symptoms of IPF tend to develop gradually and get slowly worse over time. Symptoms can include: shortness of breath, a persistent dry cough, tiredness, loss of appetite and weight loss.

IPF is a type of interstitial lung disease. It is caused by lung tissue becoming thick and stiff and eventually forming scar tissue within the lungs. The scarring, or fibrosis, seems to result from a cycle of damage and healing that occurs in the lungs. Over time, the healing process stops working correctly and scar tissue forms. What causes these changes in the first place is unknown.

5a62650652d54a3bf5733a869234a07

● Models in place 【Date➡Models】

●BLM Induced IPF Model in Rodents

【Mechanism】Bleomycin (BLM) is a drug used to treat different types of neoplasms. BLM's most severe adverse effect is lung toxicity, which induces remodeling of lung architecture and loss of pulmonary function, rapidly leading to death.

BLM is one of the most widely used drugs for inducing lung fibrosis in animals, due to its ability to provoke a histologic lung pattern similar to that described in patients undergoing chemotherapy. This pattern is characterized by patchy parenchymal inflammation, epithelial cell injury with reactive hyperplasia, epithelial-mesenchymal transition, activation and differentiation of fibroblasts to myofibroblasts, basement membrane and alveolar epithelium injuries.

bf67bce0ca1e83fae057ea4edb3026f

d2c9ce1e592d4143183be014d5c562d

c88baa389e6460a8a7dae3a1388e42a 9bc6d91a546c788e5af3b0d81051207

●SiO₂ Induced Rat IPF Model

【Mechanism】Silicosis is a fatal occupational chronic fibrotic lung disease caused by long-term exposure to respirable crystalline silica (silicon dioxide (SiO₂)) dust that was ultimately deposited in distal airways.

Upon silica particles stimulation, T lymphocytes were activated by antigen presenting cells (APC) such as dendritic cells (DC) and macrophages in the processing and presentation of silica antigen. Participation of CD4+ T cells, including Th1 and Th2 cells, in the pathogenesis of lung fibrosis induced by silica particles has been indicated in several studies.

2704191a3b66339fb78d0ac0b464c1c