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Chronic graft-versus-host disease

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Product Description

Graft-versus-host Disease (GVHD)

● Symptoms and Causes

Depending on which organs the immune system attacks, GvHD can cause symptoms ranging from rash, diarrhea, and hepatitis to potentially life-threatening bacterial, fungal, viral, or parasitic infections.

Haemopoietic-cell transplantation (HCT) is an intensive therapy used to treat high-risk haematological malignant disorders and other life-threatening haematological and genetic diseases. The main complication of HCT is graft-versus-host disease (GVHD), an immunological disorder that affects many organ systems, including the gastrointestinal tract, liver, skin, and lungs.

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doi: 10.1136/archdischild-2013-304832. Epub 2014 Jul 12.

● Models in place 【Date➡Models】

●DBA/2 lymphocyte Induced B6D2F1 cGVHD Model

【Mechanism】Autoantibody-mediated (lupus-like) cGvHD models, which exhibit a pathology similar to that of lupus, are manifested by nephritis, biliary cirrhosis, salivary gland fibrosis, lymphadenopathy, splenomegaly, autoantibody production and, to a lesser extent, skin pathology. These models are MHC mismatched and classically involve parent-to-F1 transplants that result in mixed chimerism. The most commonly studied autoantibody model is the DBA/2 → B6D2F1 model. This model results in expansion of recipient B cells, leading to lymphadenopathy, splenomegally and autoantibody production.

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