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IgA nephropathy

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Product Description

IgA nephropathy

● Symptoms and Causes

IgA nephropathy (IgAN) is the most common primary glomerulonephritis in the world. It was described as the presence of intercapillary deposits of IgA. Despite this simple description, patients with IgAN may present very broad clinical features ranging from the isolated presence of IgA in the mesangium without clinical or biological manifestations to rapidly progressive kidney failure.

IgA nephropathy often doesn't cause symptoms early on. You might not notice any health effects for 10 years or more. Sometimes, routine medical tests find signs of the disease, such as protein and red blood cells in the urine that are seen under a microscope.

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LLai, K., Tang, S., Schena, F. et al. IgA nephropathy. Nat Rev Dis Primers 2, 16001 (2016). https://doi.org/10.1038/nrdp.2016.1

● Models in place 【Date➡Models】

●BSA Induced IgA Nephropathy in BALB/c

【Mechanism】Bovine Serum Albumin (BSA) is a well-known protein that has a tendency to self-assemble into large macromolecular aggregates under a variety of conditions. BSA induced immune complexes (IC) formed either in vitro or in vivo were able to deposit on the mesangium of injected mice. These IC only formed with polymeric but not monomeric IgA and induced functional abnormalities such as proteinuria, hematuria, and glomerulonephritis in mice.

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