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Post-Surgery Pain

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Product Description

Post-Surgery Pain (PSP)

● Symptoms and Causes

Post-surgery pain, also referred to as postoperative pain, is pain a patient continues to feel after a surgical procedure. Virtually all surgical procedures will result in some level of acute pain after surgery, which refers to the expected pain felt near the surgical site as the body heals.

Surgery involves the cutting of tissues and nerves, which activate the body’s automatic injury responses such as inflammation.

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Gan TJ. Poorly controlled postoperative pain: prevalence, consequences, and prevention. J Pain Res. 2017 Sep 25;10:2287-2298. doi: 10.2147/JPR.S144066. PMID: 29026331; PMCID: PMC5626380.

● Models in place 【Date➡Models】

●Surgery Incision Induced PSP Model in Mice

【Mechanism】In order to develop novel, non-opioid therapies for the treatment of postoperative pain and identify the mechanisms underlying this pain, rodent models of incisional pain have been established. The protocol herein describes in detail how to create a mouse model of postoperative pain that was adapted from established protocols. This model of postoperative pain is frequently-used, highly reproducible, and results in peripheral and central nervous system alterations.

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