Home » Services » Autoimmune Disease Animal Models-Small Animals » Neurological System Related Diseases » Myasthenia gravis

Myasthenia gravis

Quantity:
Availability:





Inquire Add to Basket

Product Description

Myasthenia Gravis

● Symptoms and Causes

Myasthenia gravis (MG) is a chronic autoimmune disorder in which antibodies destroy the communication between nerves and muscle, resulting in weakness of the skeletal muscles. Myasthenia gravis affects the voluntary muscles of the body, especially those that control the eyes, mouth, throat and limbs. The disease can strike anyone at any age, but is more frequently seen in young women (age 20 and 30) and men aged 50 and older.

Myasthenia gravis is not inherited and it is not contagious. It generally develops later in life when antibodies in the body attack normal receptors on muscle. This blocks a chemical needed to stimulate muscle contraction.

fimmu-11-00776-9

Autoimmune Pathology in Myasthenia Gravis Disease Subtypes Is Governed by Divergent Mechanisms of Immunopathology. Front. Immunol., 27 May 2020

● Models in place 【Date➡Models】

●R97-116 peptides Induced MG Model

【Mechanism】Myasthenia gravis (MG) is an antibody-mediated, T cell-dependent, complements involved autoimmune disease, characterized by loss of acetylcholine receptor (AChR) on the postsynaptic membrane of neuromuscular junction and resulted in impaired neuromuscular transmission and muscle weakness. Experimental autoimmune myasthenia gravis (EAMG) can be induced in Lewis rats by immunization with torpedo acetylcholine receptor (TAChR) or a synthetic peptide corresponding to region 97–116 of the rat AChR α subunit (R97-116 peptide), which is a reliable model for human MG and is suitable for investigating the development of novel therapeutic strategies.

6e2cda6b4ee59c0e3a57e279082c915