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Systemic Lupus Erythematosus-NHP

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Product Description

Systemic Lupus Erythematosus (SLE)

● Symptoms and Causes

SLE is a complex heterogeneous disease characterized by autoantibody production and immune complex deposition followed by damage to target tissues. It's what most people mean when they refer to "lupus". The most common symptoms include: skin rashes, pain or swelling in the joints (arthritis), swelling in the feet, and around the eyes (typically due to kidney involvement), extreme fatigue, low fevers.

Experts don’t know what causes systemic lupus erythematosus, but lupus and other autoimmune diseases do run in families.

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Liu, Z., Davidson, A. Taming lupus—a new understanding of pathogenesis is leading to clinical advances. Nat Med 18, 871–882 (2012). https://doi.org/10.1038/nm.2752

● Models in place 【Date➡Models】

●TLR-7 Agonist Induced NHP SLE Model

【Mechanism】Several studies have demonstrated that altered Toll-like receptor (TLR) signaling contributes to the initiation and/or exacerbation of lupus in humans and in murine models. In recent years, it has become apparent that TLR-7 and TLR-9, which sense single-stranded RNA and unmethylated DNA, respectively, contribute to the development of autoimmune diseases such as rheumatoid arthritis, SLE, and psoriasis.

NHP treated with the TLR7 agonist imiquimod (IMQ) significantly up-regulated leading to systemic

autoimmune disease.

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