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Type I Diabetes

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Product Description

Type 1 Diabetes (T1D)

● Symptoms and Causes

Type 1 diabetes (T1D), also known as autoimmune diabetes. Symptoms can appear suddenly and may include: feeling more thirsty than usual, urinating a lot, bed-wetting in children who have never wet the bed during the night, feeling very hungry

The aetiology of T1D is not completely understood, the pathogenesis of the disease is thought to involve T cell-mediated destruction of β-cells. The exact cause of type 1 diabetes is unknown. Usually, the body's own immune system — which normally fights harmful bacteria and viruses — destroys the insulin-producing (islet) cells in the pancreas.

nutrients-09-01306-5

Oliveira ALB, Monteiro VVS, Navegantes-Lima KC, Reis JF, Gomes RS, Rodrigues DVS, Gaspar SLF, Monteiro MC. Resveratrol Role in Autoimmune Disease-A Mini-Review. Nutrients. 2017 Dec 1;9(12):1306. doi: 10.3390/nu9121306.

● Models in place 【Date➡Models】

●Optimized T1D Model

【Mechanism】By 20 week of age, 70–80% of NOD mice females become diabetic. By contrast, in male NOD mice, diabetes is typically delayed with only a 40–50% incidence by 30 week of age. However, a role for negative T cell signaling pathways through inhibitory receptors has been demonstrated in the initiation of disease in neonatal animals. Inhibition of the T cell receptor signaling pathway was employed in NOD mice to expedite the onset of type 1 diabetes.

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