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Thrombocytopenia

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Thrombocytopenia

signa et causas  

Thrombocytopenia immunis (ITP) est morbus heterogeneus cum complexu pathogenesis sustinetur per ansam positivi feedback. Post amissionem propriae tolerantiae, T cellulae adiutoris (Th) generationi autoanticorporum productorum cellularum B et/vel autoactivarum cellularum T cytotoxicarum promovent (Tc). Autoantibodies laminas opsonare possunt, ducens ad alvi splenicam et hepaticam per macrophages systematis reticuloendotheli. Macrophages deinde unum genus antigeni cellulae (APC) cycli propagationi servire possunt. Cellae dendriticae etiam pro APCs esse possunt. Tc cruore vel splene destruere platelets. Autoantibodia et autoreaciva Tc in medulla ossea megakaryocytae oppugnare possent, inhibentes productionem platelet. Ita ITP est inordinatio utriusque interitus et tabellionis effectio minui.

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Lv Y, Shi H, Liu H, Zhou L. Currentes consilia medicinales et prospectus in refractorio ITP: Quid nuper didicimus? Frons Immunol. 2022 Aug.



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