Thombocytopenia

Thombocytopenia

● Symptomata et causas  

Immunis ThombocyTopenia (ITP) est heteogenea morbus cum a complexu pathogenesis sustinuit a positivum feedback loop. Post damnum sui tolerantia, T adiutorium cellulis (th) promovere generationem autoantibody-producendo B cellulis et / vel autoreactive cytotoxic T cellulis (TC). Autoantibodies potest opsonets, ducens ad splenica et hepatici alvi per macrophages de reticuloendothelial ratio. Macrophages potest tunc serve sicut unum genus antigen praesentans cellula (APC), propagandae cycle. Dendritic cellulis potest etiam ut APCs. TC potest perdere platelets in sanguine vel lienis. Autoantibodies et autoreactive TC ut target megakaryocytes in os medullam, inhibentes platelet productio. Ut, ITP est inordinatio utriusque platelet exitium et minuatur platelet productio.

LV y, Shi H, Liu H, Zhou L. Current Therapeutic Strategies et Vestibulum in Refractory ITP: Quid enim didici nuper? Ante immunol. MMXXII Aug VIII; XIII: (CMLIII) DCCXVI.