| Quantity: | |
|---|---|
Clinically relevant Mimics human SLE pathogenesis: autoantibodies, interferon signature, glomerulonephritis.
TLR-7 agonist induction Reliable, reproducible model with well-defined kinetics (anti-dsDNA, IFN-α).
Multi-endpoint analysis Includes anti-dsDNA, IFN-α, complement, kidney histology, and transcriptomics.
IND-ready data packages Studies can be conducted in accordance with GLP principles.
Customizable protocols Dose optimization, combination therapy, and biomarker exploration available.
Representative data from our NHP SLE model：TLR-7 Agonist Induced NHP SLE Model
• Efficacy testing of immunomodulatory drugs (biologics, small molecules, nucleic acid therapeutics)
• Target validation for SLE and lupus nephritis
• Biomarker discovery and validation (anti-dsDNA, IFN signature, complement factors)
• IND-enabling toxicology and safety pharmacology studies
• Mechanism of action (MOA) investigations
Parameter | Specification |
Species | Cynomolgus macaque (Macaca fascicularis) |
Induction method | TLR-7 agonist (imiquimod) topical + repeated dosing |
Study duration | 4–12 weeks (depending on endpoints) |
Key endpoints | Anti-dsDNA, ANA, IFN-α, complement C3/C4, kidney histology (H&E, IF), RNA-seq |
Data package | Raw data, analysis reports, IHC slides, bioinformatics (optional) |
Q: How is the SLE model induced?
A: By repeated topical application of a TLR-7 agonist (e.g., imiquimod), leading to systemic autoimmunity with autoantibody production and kidney involvement.
Q: Can this model be used for IND-enabling studies?
A: Yes. We can perform studies in accordance with GLP principles; data packages are designed to support regulatory submissions (FDA, EMA).
Q: Do you offer customized study protocols?
A: Absolutely. Our scientific team tailors induction regimens, dosing schedules, and endpoint analyses to your drug candidate and MOA.
Q: What is the typical timeline for a pilot efficacy study?
A: Pilot studies (n=3-4/group) can be completed in 8–10 weeks, including model induction, treatment, and initial data analysis.