Air pouch Model

Air pouch Model 

● Symptoms and Causes  

The Air Pouch Eosinophilia model involves creating a sealed air pouch subcutaneously in the animal's back, serving as a tool to investigate eosinophil functions in inflammation. Following subcutaneous injection of OVA to induce allergic inflammation, eosinophils are chemotaxed into the pouch through the synergistic effects of IL-5 and hCCL11. This model is instrumental in evaluating the efficacy of anti-inflammatory drugs and developing novel therapeutic strategies for eosinophil-related diseases, making it a significant tool in immunology and pharmaceutical research.

https://doi.org/10.3390/biomedicines10092181