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Urticaria

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Urticaria

● Symptoms and Causes  

Urticaria is classified, first, based on its duration as acute urticaria, lasting ≤6 weeks, or chronic urticaria (CU), lasting >6 weeks4. 

Urticaria is further divided into inducible and spontaneous forms. In inducible urticaria, the signs and symptoms are induced by a subtype-specific and definite trigger, for example cold in cold urticaria (ColdU). In spontaneous urticaria, the signs and symptoms appear unprompted, and there are no definite triggers, although stress, infections and other aggravators can increase disease activity in some patients. Spontaneous urticaria is more common than inducible urticaria and both can coexist in the same patient.

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https://doi.org/10.1038/s41572-022-00389-z


 ● Models in place 【Date➡Models】

OVA Induced BALB/c Urticaria Model

【Mechanism】Ovalbumin (OVA) is the main protein found in egg white, which is not intrinsically immunogenic and therefore needs to be injected systemically in the presence of adjuvants, typically aluminum hydroxide (alum), to induce Th2 sensitization in mice.

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