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Vitiligo

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Product Description

Vitiligo

● Symptoms and Causes

Vitiligo signs include: Patchy loss of skin color, which usually first appears on the hands, face, and areas around body openings and the genitals. The condition can affect the skin on any part of the body. It can also affect hair and the inside of the mouth.

Vitiligo occurs when cells that produce melanin die or stop functioning. The progression of vitiligo, a skin disorder that presents as loss of melanocytes, has been associated with the presence of CD8+Tcells specific for melanocyte differentiation antigen.

fimmu-11-618897-12

doi: 10.3389/fimmu.2020.618897.

● Models in place 【Date➡Models】

●Vitiligo Mouse Model

【Mechanism】This model relies on transient inoculation of B16F10 melanoma cells and depletion of CD4+ regulatory T cells.This vitiligo mouse model by activating endogenous auto-reactive CD8+ T cells to target epidermal melanocytes.

It recapitulates all the hallmarks of human vitiligo disease at phenotypic, histological and signaling levels, enables researchers to carry out in-depth in vivo vitiligo studies utilizing mouse genetics tools, and provides a powerful platform for drug discovery.

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