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Chronic Obstructive Pulmonary Disease

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Chronic Obstructive Pulmonary Disease(COPD) 

● Symptoms and Causes  

Chronic obstructive pulmonary disease (COPD) is a chronic inflammatory lung disease that causes obstructed airflow from the lungs. Symptoms include breathing difficulty, cough, mucus (sputum) production and wheezing. 

It's typically caused by long-term exposure to irritating gases or particulate matter, most often from cigarette smoke. People with COPD are at increased risk of developing heart disease, lung cancer and a variety of other conditions.

jtd-11-S17-S2129-3

doi:10.21037/jtd.2019.10.43


 ● Models in place 【Date➡Models】

COPD Model in C57BL/6 Mice

【Mechanism】A cigarette smoke (CS)-induced model remains one of the most popular because it not only simulates COPD-like lesions in the respiratory system, but it is also based on one of the main hazardous materials that causes COPD in humans. 

6aacfc05c65410490b1a2f6caa49b37b766eeb1700efb8f92fdb7cbe59d3b7慢性阻塞性肺疾病 COPD模型介绍-20240425_20240617102756



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