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Knee Osteoarthritis

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Product Description

Knee Osteoarthritis (KOA)

● Symptoms and Causes

Knee osteoarthritis (KOA) is a common pathology, leading to chronic disability. Its prevalence increases with age: up to 80 percent of people over the age of 65 suffer from OA in high-income countries.

There are several factors that can increase the risk of developing osteoarthritis and impact the rate at which OA progresses over time. The most general cause of joint osteoarthritis is joint. Body weight，age，family history and past joint injury can add increased pressure.

fimmu-12-678757-3

Thomson A, Hilkens CMU. Synovial Macrophages in Osteoarthritis: The Key to Understanding Pathogenesis? Front Immunol. 2021 Jun 15;12:678757. doi: 10.3389/fimmu.

● Models in place 【Date➡Models】

●MIA Induced KOA Model

【Mechanism】The chemical induction method most frequently used with the murine model involves an intracapsular injection of monoiodoacetate (MIA). MIA is a blocker of chondrocyte aerobic glycolysis that induces apoptosis.

KOA induction by MIA is indicated when exploring OA-related pain and is often recommended for pain-related studies.

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