NHP collagen-induced arthritis (CIA) model

Rheumatoid arthritis (RA) is a chronic autoimmune disease characterized by inflammatory polyarthritis that leads to the destruction of cartilage and bone. HKeyBio offers a well-validated NHP collagen-induced arthritis (CIA) model established by immunization with type II collagen (CII). This model recapitulates key clinical and histological features of human RA, including joint swelling, elevated anti-collagen IgG, and increased acute phase proteins (CRP, ALP). It provides a powerful platform for preclinical efficacy testing of novel RA therapies.

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Product Description

Main features and benefits

Clinically relevant – Mimics human RA pathogenesis: autoimmune polyarthritis, cartilage destruction, systemic inflammation.

Well characterized endpoints – clinical score, body weight, anti-collagen IgG, acute phase proteins (CRP, ALP), joint histopathology.

Reproducible induction – High incidence of susceptible NHP strains.

Translational Value – Ideal for testing disease-modifying antirheumatic drugs (DMARDs), biologics, and targeted immunomodulators.

IND Ready Packet – Research can be conducted in accordance with GLP principles.

Technical data and verification

Representative data for our NHP CIA model:

Collagen-induced arthritis model

Application areas

• Efficacy testing of DMARDs, biologics (anti-TNF, anti-IL-6R), JAK inhibitors

• Target validation of autoimmune arthritis pathways

• Biomarker discovery (anti-collagen antibodies, acute phase proteins)

• Mechanism of action (MOA) studies

• Toxicology and safety pharmacology studies to support IND

Model specifications

scope	Specification
Species	cynomolgus monkey ( Macaca fascicularis )
induction method	Immunization with type II collagen (CII) in adjuvants such as CFA/IFA
study time	8-12 weeks after vaccination
critical endpoint	Body weight, clinical arthritis score, anti-collagen IgG, CRP, ALP, joint histopathology, radiology (optional)
packet	Raw data, analysis reports, histology slides, bioinformatics (optional)

❓ FAQ

Q: How is the CIA model induced in NHP?

A: Immunization is performed with native type II collagen (CII) emulsified in Complete Freund's Adjuvant (CFA), followed by a booster injection. This triggers an autoimmune response against the joint cartilage.

Q: What are the main similarities to human RA?

A: This model exhibits symmetric polyarthritis, synovial hyperplasia, pannus formation, cartilage erosion, and autoantibodies (anti-CII IgG), very similar to human RA pathology.

Q: Can this model be used for IND support studies?

Answer: Yes. Studies can be conducted according to GLP principles for regulatory submissions (FDA, EMA).

Q: Do you offer customized study protocols (e.g. different adjuvants, dosing regimens)?

Answer: Of course. Our scientific team tailors immunization regimens, treatment plans and endpoint analyzes to your specific drug candidate.