| Quantity: | |
|---|---|
Clinically relevant – Cisplatin-induced neuropathy mimics human CIPN with sensory deficits, pain, and weight changes.
Multiple species Quantifiable endpoints Translational value IND-ready data packages - Studies can be conducted in accordance with GLP principles.
Cisplatin Induced SD CIPN Model
Cisplatin Induced C57BL/6 CIPN Model
• Efficacy testing of neuroprotective agents (acetyl-L-carnitine, vitamin E, glutathione, amifostine)
• Evaluation of analgesic drugs (gabapentin, pregabalin, duloxetine, tricyclic antidepressants) for neuropathic pain
• Target validation for neuropathic pain pathways and nerve regeneration strategies
• Biomarker discovery (neurofilament light chain, inflammatory mediators)
• IND-enabling pharmacology and toxicology studies
Parameter | Rat CIPN Model | Mouse CIPN Model |
Species/Strain | Sprague-Dawley rat | C57BL/6 mouse |
Induction method | Cisplatin i.p. 2–4 mg/kg, 2–3 times/week for 2–5 weeks | Cisplatin i.p. 2–3 mg/kg, 2–3 times/week for 2–4 weeks |
Study duration | 3–6 weeks (induction + treatment) | 3–5 weeks (induction + treatment) |
Key endpoints | Body weight, mechanical withdrawal threshold (von Frey), optional: thermal sensitivity (hot plate, Hargreaves), nerve conduction velocity, histopathology (nerve morphology), intraepidermal nerve fiber density | |
Data package | Raw data, analysis reports, behavioral data, histology slides (optional), bioinformatics (optional) | |
A1: We establish cisplatin-induced Chemotherapy Induced Peripheral Neuropathy (CIPN) models using SD rats and C57BL/6 mice for preclinical research.
A2: Cisplatin has high affinity for the peripheral nervous system. It damages peripheral sensory and motor nerves, resulting in nerve degeneration and typical neuropathy symptoms similar to clinical CIPN.
A3: We monitor body weight dynamically and test paw withdrawal threshold to evaluate sensory nerve dysfunction and pain behaviors.
A4: Cisplatin is administered once a week starting from Day 0. The whole experiment lasts 35 days for rats and 18 days for mice respectively.
