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Idiopathic thrombocytopenic purpura

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Product Description

Idiopathic Thrombocytopenic Purpura

● Symptoms and Causes

Idiopathic thrombocytopenic purpura is a blood disorder characterized by an abnormal decrease in the number of platelets in the blood. Platelets are cells in the blood that help stop bleeding. A decrease in platelets can result in easy bruising, bleeding gums and internal bleeding. ITP occurs when certain immune system cells produce antibodies against platelets. Platelets help your blood clot by clumping together to plug small holes in damaged blood vessels. The antibodies attach to the platelets. The body destroys the platelets that carry the antibodies.

Symptoms may include: petechiae, purpura, bruises, bleeding gums, blood in poop (stool), blood in urine (pee), heavy menstrual periods, heavy nosebleeds, hematoma (large bruise).

jcm-06-00016-v2-6

Pathogenesis and Therapeutic Mechanisms in Immune Thrombocytopenia (ITP). J. Clin. Med. 2017, 6, 16.

● Models in place 【Date➡Models】

●Anti-CD41 antibody Induced ITP Model

【Mechanism】From among several passive antibody transfer ITP models developed, most laboratories utilize the anti-CD41antibody model, which is based on a self-antigen that is highly relevant to the human disorder. The infusion of the anti-CD41 antibody leads to a rapid onset ITP with clear involvement of the phagocytic monocytes in platelet destruction. The passive antibody transfer-induced ITP model also offers a degree of tunability, allowing for the severity and persistence of the ITP to be controlled by adjusting the dosage and frequency of the antiplatelet antibody administered. Repeat administration of the anti-CD41 antibody, with a dose-escalation regimen, maintains a prolonged thrombocytopenia that closely resembles chronic human ITP.

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