| Quantity: | |
|---|---|
Etiologically relevant – Induced by cigarette smoke, the primary cause of human COPD.
Clinically translatable endpoints – Lung function testing, chest CT imaging, BALF cytology (neutrophils), body weight monitoring.
Chronic inflammation – Reproducible airway neutrophilia and structural lung damage.
Multi-system evaluation – Assess both pulmonary and systemic effects of test compounds.
IND-ready data packages – Studies can be conducted in accordance with GLP principles.
Representative data from our Cigarette Smoke Induced NHP COPD model:
Smoke induced COPD Model in NHP
• Efficacy testing of anti-inflammatory drugs for COPD (e.g., PDE4 inhibitors, corticosteroids, biologics)
• Target validation for neutrophil-mediated airway diseases
• Biomarker discovery (BALF cytology, cytokines, imaging biomarkers)
• Mechanism of action (MOA) studies
• IND-enabling toxicology and safety pharmacology studies
Parameter | Specification |
Species | Cynomolgus macaque (Macaca fascicularis) |
Induction method | Chronic whole-body or nose-only exposure to cigarette smoke (daily, 3-6 months) |
Study duration | 3–6 months (induction phase) + treatment phase |
Key endpoints | Body weight, lung function (spirometry), BALF cytology (neutrophils), chest CT imaging, histopathology (optional) |
Data package | Raw data, analysis reports, CT images, BALF cytology reports, bioinformatics (optional) |
Q: How is the COPD model induced in NHP?
A: By chronic exposure to cigarette smoke over several months, mimicking the primary human etiology of COPD.
Q: What are the key pathological features of this model?
A: Airway inflammation (neutrophilia in BALF), progressive lung function decline, and emphysematous changes visible on CT imaging.
Q: Can this model be used for IND-enabling studies?
A: Yes. Studies can be conducted in accordance with GLP principles for regulatory submissions (FDA, EMA).
Q: How long does a typical efficacy study take?
A: Total study duration including COPD induction and treatment phase is approximately 4–8 months, depending on endpoints and study design.
