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Gouty Arthritis

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Product Description

Gouty arthritis (GA)

● Symptoms and Causes

Epidemiology, cause and symptoms ：Gout is the most common inflammatory arthritis with about 2–4% of prevalence worldwide, mainly in men over 40 and particularly in those with underlying comorbidities such as obesity, hypertension, coronary artery disease, diabetes, or metabolic diseases. The characteristic gouty flare has a distinctive clinical feature, achieving an acute painful synovitis caused by monosodium urate (MSU) crystals deposition in joints.

GA as an Autoimmune disease: MSU triggered the activation of NLRP3, which was the key biomarker in the cycle of GA inflammation. NLRP3 increases the presentation of IL-1β and IL-18，then the neutrophil gathered and degranulation in the joint，which causes the joint inflammation.

Molecular Pathophysiology of Gout(科研通-ablesci.com)-6

Desai J, Steiger S, Anders HJ. Molecular Pathophysiology of Gout. Trends Mol Med. 2017;23(8):756-768. doi:10.1016/j.molmed.2017.06.005

● Models in place 【Date➡Models】

●MSU Induced GA Model in mice

【Mechanism】Monosodium urate (MSU) crystals, the etiological agent of gout, are formed in joints and periarticular tissues due to long-lasting hyperuricemia. MSU crystal-triggered NLRP3 inflammasome activation and interleukin 1β (IL-1β) release are known to have key roles in gouty arthritis, recent studies revealed that MSU crystal-induced necrosis also plays a critical role in this process.

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